How Semaglutide Works
Semaglutide mimics GLP-1, a hormone naturally released after eating. It binds to GLP-1 receptors in the brain and gut, reducing appetite, slowing gastric emptying, and improving insulin sensitivity. The result is a significant reduction in hunger and caloric intake over time.
Unlike stimulant-based appetite suppressants, semaglutide works through hormonal signaling rather than central nervous system stimulation. It is administered as a once-weekly subcutaneous injection and is titrated gradually to minimize side effects.
Clinical trials of semaglutide for weight management (the STEP trial program) showed average weight loss of approximately 15% of body weight over 68 weeks in adults with obesity. Individual results vary and are not guaranteed.
Who It's For
A licensed provider will evaluate your complete health history before recommending semaglutide. In general, it may be considered for adults who:
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Have a BMI of 30 or higher, or a BMI of 27 or higher with a weight-related condition such as high blood pressure, type 2 diabetes, or high cholesterol
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Have not achieved adequate results through diet and exercise alone
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Do not have contraindicated conditions (including personal or family history of medullary thyroid carcinoma or MEN 2)
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Are not pregnant or planning to become pregnant during treatment
Only a licensed healthcare provider can determine whether semaglutide is appropriate for you. This is not medical advice.
How the Program Works
01
Complete Your Online Evaluation
Answer questions about your health history, current medications, and weight loss goals through our clinical partner's HIPAA-compliant portal.
02
Provider Review
A licensed healthcare professional independently reviews your information and determines whether semaglutide is medically appropriate for you.
03
Prescription & Pharmacy Fulfillment
If approved, your prescription is filled by a licensed US-based 503A compounding pharmacy or FDA-registered 503B outsourcing facility and shipped directly to you.
04
Ongoing Support
Your provider monitors your progress, adjusts your dose as needed, and is available through your patient portal for questions and check-ins.
Pricing
Starting at $129 / month
Starting price. Final cost depends on your prescribed dosage and program length. You will see your full cost before checkout — no hidden fees.
Compounded vs. Brand-Name Semaglutide
Brand-name
Brand-name semaglutide products (Ozempic® and Wegovy®) are FDA-approved drugs manufactured under strict FDA oversight. They have undergone rigorous clinical trials for safety, efficacy, and manufacturing quality.
Compounded
Compounded semaglutide is prepared by state-licensed 503A compounding pharmacies or FDA-registered 503B outsourcing facilities. Compounded semaglutide is not FDA-approved — it has not been evaluated by the FDA for safety, efficacy, or quality in the same way brand-name drugs have. Compounding is legally permitted under specific circumstances, including when an FDA-approved drug is on the FDA shortage list.
LeoCore Health's clinical partner works exclusively with licensed US-based compounding pharmacies and FDA-registered outsourcing facilities. Patients should discuss the specific medication being prescribed with their licensed provider.
Ready to Take the Next Step?
Start with a confidential online evaluation. A licensed provider will review your health history and goals to determine whether treatment may be appropriate for you.
Individual results may vary. Treatment is subject to provider evaluation and approval. LeoCore Health does not provide medical care directly.
Side Effects and Safety
Semaglutide is generally well tolerated, but side effects are common — particularly during dose escalation. Understanding what to expect can help you communicate effectively with your provider.
Nausea
The most common side effect, especially in the first few weeks. Usually improves as the body adjusts. Eating smaller meals and avoiding high-fat foods can help.
Vomiting and diarrhea
Less common than nausea. Typically transient and manageable with dietary adjustments.
Constipation
Occurs in some patients. Increased fiber and hydration are typically recommended.
Fatigue
Some patients report low energy early in treatment, often related to reduced caloric intake. Generally resolves as the body adapts.
Serious adverse events are rare but possible, including pancreatitis and gallbladder disease. Semaglutide carries a boxed warning for patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Seek immediate medical attention for severe abdominal pain, persistent vomiting, or signs of an allergic reaction.
Read the full side effects guide →
Frequently Asked Questions
Is semaglutide the same as Ozempic or Wegovy?
Semaglutide is the active ingredient in both Ozempic® (approved for type 2 diabetes) and Wegovy® (approved for weight management). Compounded semaglutide contains the same active ingredient but is not FDA-approved and is not manufactured by the same companies. Your provider will discuss which form is being prescribed.
How long does it take to see results?
Individual responses vary. Some patients notice reduced appetite within the first few weeks. Clinically meaningful weight changes are typically observed over three to six months of treatment. Results are not guaranteed and depend on many individual factors.
Do I need a prescription?
Yes. Semaglutide is a prescription medication. A licensed provider must evaluate your health history and determine whether it is medically appropriate for you before a prescription can be issued.
What happens if I stop taking semaglutide?
Clinical research suggests that weight regain is common after stopping GLP-1 medications. Your provider will discuss a long-term plan that may include continued treatment, dose adjustments, or lifestyle strategies to support sustained results.
Is semaglutide covered by insurance?
Insurance coverage varies widely. Many plans do not cover semaglutide for weight management specifically. LeoCore Health offers transparent starting prices for compounded semaglutide programs — see our pricing page for details.
How is semaglutide administered?
Semaglutide for weight management is administered as a once-weekly subcutaneous (under the skin) injection, typically in the abdomen, thigh, or upper arm. Your provider will give you instructions on self-injection technique.
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