How Sermorelin Works
As we age, the pituitary gland naturally produces less growth hormone. Sermorelin binds to GHRH receptors in the pituitary gland, stimulating it to produce and secrete growth hormone in a pulsatile, physiologically normal pattern. This is distinct from exogenous growth hormone therapy, which introduces growth hormone directly.
Sermorelin is typically administered as a subcutaneous injection, often at bedtime to align with the body's natural growth hormone release cycle. Protocols vary by individual and are determined by a licensed provider based on your health history and goals.
Sermorelin is a compounded peptide. Compounded sermorelin is not FDA-approved and has not been evaluated by the FDA for safety, efficacy, or quality in the same way FDA-approved drugs have. A licensed provider must determine whether it is appropriate for you.
Who It's For
A licensed provider will evaluate your complete health history before recommending sermorelin. It may be considered for adults who:
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Are experiencing symptoms potentially associated with age-related decline in growth hormone, such as reduced energy, changes in body composition, or impaired recovery
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Are interested in supporting healthy aging and vitality under physician guidance
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Do not have contraindicated conditions, including active malignancy or certain pituitary disorders
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Are not pregnant or planning to become pregnant during treatment
Only a licensed healthcare provider can determine whether sermorelin is appropriate for you. This is not medical advice.
How the Program Works
01
Complete Your Online Evaluation
Answer questions about your health history, symptoms, and wellness goals through our clinical partner's HIPAA-compliant portal.
02
Provider Review
A licensed healthcare professional independently reviews your information and determines whether sermorelin is medically appropriate for you.
03
Prescription & Pharmacy Fulfillment
If approved, your prescription is filled by a licensed US-based 503A compounding pharmacy and shipped directly to you.
04
Ongoing Support
Your provider monitors your progress, adjusts your protocol as needed, and is available through your patient portal for questions and check-ins.
About Compounded Sermorelin
Brand-name
There is no currently FDA-approved brand-name sermorelin product available in the US market. Sermorelin was previously available as Geref® but was discontinued.
Compounded
Compounded sermorelin is prepared by state-licensed 503A compounding pharmacies. Compounded sermorelin is not FDA-approved — it has not been evaluated by the FDA for safety, efficacy, or quality. Compounding is legally permitted under specific circumstances defined by federal and state law.
LeoCore Health's clinical partner works exclusively with licensed US-based compounding pharmacies. Patients should discuss the specific medication being prescribed with their licensed provider.
Ready to Take the Next Step?
Start with a confidential online evaluation. Our physicians will review your health history and goals to recommend the right treatment path for you.
Individual results may vary. Treatment is subject to provider evaluation and approval. LeoCore Health does not provide medical care directly.
Side Effects and Safety
Sermorelin is generally considered well tolerated. Side effects are typically mild and may include:
Injection site reactions
Redness, swelling, or discomfort at the injection site. Rotating injection sites helps minimize this.
Flushing
Some patients report a warm or flushed feeling shortly after injection. Usually brief and mild.
Headache
Reported by some patients, particularly early in treatment. Usually transient.
Dizziness or lightheadedness
Uncommon. Patients should avoid driving or operating heavy machinery if they experience this.
Sermorelin should not be used in patients with active malignancy or a history of certain pituitary tumors. Because sermorelin stimulates growth hormone production, it may theoretically promote growth of existing tumors. A licensed provider must review your complete medical history before prescribing.
Learn about peptide therapy →
Frequently Asked Questions
Is sermorelin the same as HGH?
No. Sermorelin is a growth hormone-releasing hormone (GHRH) analog that stimulates the pituitary gland to produce its own growth hormone. HGH (human growth hormone) is the hormone itself, administered directly. Sermorelin works indirectly through the body's own regulatory systems.
Is sermorelin FDA-approved?
Compounded sermorelin is not FDA-approved. There is no currently available FDA-approved brand-name sermorelin product in the US market. Compounding is legally permitted under specific circumstances defined by federal and state law.
Do I need a prescription?
Yes. Sermorelin is a prescription compound. A licensed provider must evaluate your health history and determine whether it is medically appropriate for you before a prescription can be issued.
How long before I notice effects?
Individual responses vary. Some patients report changes in sleep quality and energy within the first few weeks. Changes in body composition, if they occur, are typically observed over several months of consistent treatment. Results are not guaranteed.
When is sermorelin typically administered?
Sermorelin is often administered at bedtime to align with the body's natural growth hormone release cycle, which peaks during deep sleep. Your provider will give you specific instructions based on your protocol.
Can sermorelin be combined with other peptides?
Some providers prescribe sermorelin in combination with other peptides such as ipamorelin (a growth hormone secretagogue). Your licensed provider will determine the most appropriate protocol based on your individual health history and goals.
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