How NAD+ Therapy Works
NAD+ is essential for the function of sirtuins (proteins involved in cellular health and longevity) and PARPs (enzymes involved in DNA repair). As NAD+ levels decline with age, these processes become less efficient. Supplementing NAD+ — or its precursors — aims to restore cellular function by replenishing this critical coenzyme.
NAD+ can be administered via subcutaneous injection or intravenously. Injectable protocols allow for more direct delivery compared to oral supplements, which have variable absorption. Your licensed provider will determine the most appropriate form and dosing based on your health history and goals.
Research on NAD+ therapy is ongoing. While preclinical and early clinical studies are promising, large-scale randomized controlled trials in humans are still limited. A licensed provider will discuss the current state of evidence with you before prescribing.
Who It's For
A licensed provider will evaluate your complete health history before recommending NAD+ therapy. It may be considered for adults who:
✓
Are interested in supporting healthy aging, cellular energy, and cognitive function
✓
Are experiencing symptoms potentially associated with age-related cellular decline, such as fatigue or reduced mental clarity
✓
Do not have contraindicated conditions
✓
Are not pregnant or planning to become pregnant during treatment
Only a licensed healthcare provider can determine whether NAD+ therapy is appropriate for you. This is not medical advice.
How the Program Works
01
Complete Your Online Evaluation
Answer questions about your health history, symptoms, and wellness goals through our clinical partner's HIPAA-compliant portal.
02
Provider Review
A licensed healthcare professional independently reviews your information and determines whether NAD+ therapy is medically appropriate for you.
03
Prescription & Pharmacy Fulfillment
If approved, your prescription is filled by a licensed US-based 503A compounding pharmacy and shipped directly to you.
04
Ongoing Support
Your provider monitors your progress, adjusts your protocol as needed, and is available through your patient portal for questions and check-ins.
About Compounded NAD+
FDA status
There are no currently FDA-approved injectable NAD+ products for the indications described here. Some oral NAD+ precursor supplements (such as NMN and NR) are available over the counter, though their bioavailability and efficacy compared to injectable NAD+ are areas of ongoing research.
Compounded
Injectable NAD+ is prepared by state-licensed 503A compounding pharmacies. Compounded NAD+ is not FDA-approved — it has not been evaluated by the FDA for safety, efficacy, or quality. Compounding is legally permitted under specific circumstances defined by federal and state law.
LeoCore Health's clinical partner works exclusively with licensed US-based compounding pharmacies. Patients should discuss the specific medication being prescribed with their licensed provider.
Ready to Take the Next Step?
Start with a confidential online evaluation. Our physicians will review your health history and goals to recommend the right treatment path for you.
Individual results may vary. Treatment is subject to provider evaluation and approval. LeoCore Health does not provide medical care directly.
Side Effects and Safety
NAD+ therapy is generally considered well tolerated. Side effects are typically mild and may include:
Injection site reactions
Redness, swelling, or discomfort at the injection site. Rotating injection sites helps minimize this.
Flushing or warmth
Some patients report a warm or flushed sensation. Usually brief and mild.
Nausea
Reported by some patients, particularly at higher doses. Usually transient.
Headache or fatigue
Uncommon. Usually resolves as the body adjusts to treatment.
The long-term safety profile of high-dose NAD+ supplementation in humans is not yet fully established. Patients with a history of cancer should discuss NAD+ therapy carefully with their provider, as NAD+ plays a role in cellular energy metabolism that may have implications in certain oncological contexts.
Learn about healthy aging →
Frequently Asked Questions
What is NAD+ and why does it decline with age?
NAD+ is a coenzyme essential for energy metabolism, DNA repair, and cellular signaling. Levels naturally decline with age due to increased consumption by DNA repair enzymes and reduced biosynthesis. This decline has been associated with reduced cellular energy and aspects of the aging process.
Is injectable NAD+ better than oral supplements?
Injectable NAD+ bypasses the digestive system, potentially allowing for more direct delivery to cells. Oral NAD+ precursors (NMN, NR) are absorbed through the gut and converted to NAD+ in the body. The comparative efficacy of these approaches is an area of ongoing research. Your provider can discuss which form may be most appropriate for you.
Do I need a prescription for NAD+ injections?
Yes. Injectable compounded NAD+ requires a prescription from a licensed healthcare provider who has evaluated your health history and determined that treatment is appropriate for you.
How quickly will I notice effects?
Individual responses vary. Some patients report improved energy and mental clarity within the first few weeks. Results are not guaranteed and depend on many individual factors.
Is NAD+ therapy FDA-approved?
There are no currently FDA-approved injectable NAD+ products for the wellness indications described here. Compounded NAD+ is not FDA-approved. Compounding is legally permitted under specific circumstances defined by federal and state law.
Can NAD+ therapy be combined with other treatments?
Some patients use NAD+ therapy alongside other wellness protocols. Your licensed provider will evaluate your complete health history and current medications before making any recommendations.
RELATED